Preheat your oven to 350°F (175°C). Gather your ingredients and tools.

In a large bowl, combine ground beef, pork rinds, egg, Worcestershire sauce, onion powder, salt, and garlic powder. Mix until well blended.

Press half the mixture into the bottom of the loaf pan, creating a deep indentation in the center.

Cube the American cheese and place it in the center indentation, then cover with the remaining meat mixture.

Bake for 60 to 70 minutes, until juices run clear and the internal temperature reaches 160°F (71°C).

While the meatloaf is baking, mix together mayonnaise, dill pickle relish, mustard, wine vinegar, paprika, and garlic powder for the sauce.

Let the meatloaf rest for 10 minutes after baking, then slice and drizzle with Big Mac sauce before serving.